(CNN) Colin Powell, the first Black US secretary of state whose leadership in several Republican administrations helped shape American foreign policy in the last years of the 20th century and the early years of the 21st, has died from complications from Covid-19, his family said on Facebook. He was 84.

General Colin L. Powell, former U.S. Secretary of State and Chairman of the Joint Chiefs of Staff, passed away this morning due to complications from Covid 19,” the Powell family wrote on Facebook, noting he was fully vaccinated.

A source familiar with the matter said Powell had multiple myeloma, a cancer of plasma cells that suppresses the body’s immune response. Even if fully vaccinated against Covid-19, those who are immunocompromised are at greater risk from the virus.

“We have lost a remarkable and loving husband, father, grandfather and a great American,” the family said.

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